Monday, April 18, 2011

On the Shoulders of Mice

We excerpt, from a report on this research, which illustrates a combination of creative and destructive forces necessary for healthy neuron activity, Not one or the other, but both, are necessary. Of course one can hardly expect scientists to appreciate the possibility of three currents:

Researchers at Johns Hopkins have discovered in mice a molecular wrecking ball that powers the demolition phase of a cycle that occurs at synapses — those specialized connections between nerve cells in the brain — and whose activity appears critical for both limiting and enhancing learning and memory.

The newly revealed protein, which the researchers named thorase after Thor, the Norse god of thunder, belongs to a large family of enzymes that energize not only neurological construction jobs but also deconstruction projects. The discovery is described in the April 15 issue of Cell.....

“Change in the strength of the connections between two nerve cells forms the basis of our ability to learn and remember,” Dawson says. This phenomenon, called synaptic plasticity, depends upon a balanced alternation of excitation and inhibition of receptors,

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