Let's Just Get a Pitcher

The evidence of antibiotic use, found in Nubian mummies from 2000 years ago, did not result from accidental intake,  according to the article excerpted below:

...Said co-author George Armelagos, a biological anthropologist at Emory University in Atlanta.
""They may not have known what tetracycline was, but they certainly knew something was making them feel better."

Armelagos was part of a group of anthropologists that excavated the mummies in 1963. His original goal was to study osteoporosis in the Nubians, who lived between about 350 and 550 A.D. But while looking through a microscope at samples of the ancient bone under ultraviolet light, he saw what looked like tetracycline -- an antibiotic that was not officially patented in modern times until 1950.

At first, he assumed that some kind of contamination had occurred...

His team's first report about the finding, bolstered by even more evidence and published in Science in 1980, was met with lots of skepticism. For the new study, he got help dissolving bone samples and extracting tetracycline from them, clearly showing that the antibiotic was deposited into and embedded within the bone, not a result of contamination from the environment.

The analyses also showed that ancient Nubians were consuming large doses of tetracycline -- more than is commonly prescribed today as a daily dose for controlling infections...  The team, including chemist Mark Nelson of Paratek Pharmaceuticals, reported their results in the American Journal of Physical Anthropology.

They were also able to trace the antibiotic to its source: Grain that was contaminated with a type of mold-like bacteria called Streptomyces. Common in soil, Strep bacteria produce tetracycline antibiotics to kill off other, competing bacteria.

Grains that are stored underground can easily become moldy with Streptomyces contamination, though these bacteria would only produce small amounts of tetracycline on their own when left to sit or baked into bread. Only when people fermented the grain would tetracycline production explode. Nubians both ate the fermented grains as gruel and used it to make beer.

The scientists are working now to figure out exactly how much tetracycline Nubians were getting, but it appears that doses were high that consumption was consistent, and that drinking started early. Analyses of the bones showed that babies got some tetracycline through their mother's milk.

Then, between ages two and six, there was a big spike in antibiotics deposited in the bone, Armelagos said, suggesting that fermented grains were used as a weaning food.

Today, most beer is pasteurized to kill Strep and other bacteria, so there should be no antibiotics in the ale you order at a bar, said Dennis Vangerven, an anthropologist at the University of Colorado, Boulder.

But Armelagos has challenged his students to home-brew beer like the Nubians did, including the addition of Strep bacteria. The resulting brew contains tetracycline, tastes sour but drinkable, and gives off a greenish hue.

There's still a possibility that ancient antibiotic use was an accident that the Nubians never knew about, though Armelagos has also found tetracycline in the bones of another population that lived in Jordan. And VanGerven has found the antibiotic in a group that lived further south in Egypt during the same period...